Proton pump inhibitors

PPIs are effective for the short-term (8-12 weeks) treatment of gastro esophageal reflux disease. However, long-term PPI use is associated with an increase in adverse effects including clostridium difficile infection, community-acquired pneumonia, hip fractures, renal complications and vitamin B12 and magnesium deficiency.

Long term PPI use is recommended for the following conditions:

  • Barrett’s esophagus,

  • Zollinger-Ellison syndrome,

  • Severe esophagitis,

  • Chronic use of NSAIDs in patients at risk of bleeding

  • Documented history of bleeding GI ulcer

For all other indications, including when the indication is unknown, clinical practice guidelines recommend a trial of deprescribing.

What tools are available for PPI deprescribing?

Inhibiteurs de la pompe à protons

PPIs are effective for the short-term (8-12 weeks) treatment of gastro esophageal reflux disease. However, long-term PPI use is associated with an increase in adverse effects including clostridium difficile infection, community-acquired pneumonia, hip fractures, renal complications and vitamin B12 and magnesium deficiency.

Long term PPI use is recommended for the following conditions:

  • Barrett’s esophagus,

  • Zollinger-Ellison syndrome,

  • Severe esophagitis,

  • Chronic use of NSAIDs in patients at risk of bleeding

  • Documented history of bleeding GI ulcer

For all other indications, including when the indication is unknown, clinical practice guidelines recommend a trial of deprescribing.

What tools are available for PPI deprescribing?